Performance limits in industrial chromatographic separation processes

Performance limits in large scale simulated moving bed ion exclusion or ligand exchange chromatography are imposed by three basic variables, process design, column design and resin kinetics. A column design with specific internal flow straighteners has been developed to meet the need for uniform cross-sectional distribution/collection, and vertical plug flow in large industrial size chromatography columns by dividing the cross-sectional area of the column into smaller segments. It is suggested that maximum operating efficiency will be obtained through the use of minimum resin particle size and narrow particle size distribution to maintain uniform sorption and de-sorption rates. Commercially available resins are tested in respect to their separating efficiency. It was demonstrated that gel-type cation exchange resins which have similar measurable properties such as % crosslinking (water content), operating capacity, mean particle size and particle size distribution, display similar kinetic properties in pulse tests for separating sucrose from nonsugars.

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